In this issue,we pick up with Deadpool drifting in the escape pod. He bumps into a bunch of creatures that are all the last of their race and because Deadpool fights and wins against the toughest of them, Deadpool is now their leader. They ask him to go free one of their own, Dirty Wolff, who is locked up in a prison in a barren asteroid. Disguising himself as one of the guards, Deadpool slips in and grabs Dirty Wolff.

In this issue, we pick up with Deadpool calling back to his roommates to tell them that he needs a ride back to Earth. Then we get a flashback of when Deadpool encountered Humbug and went temporarily deaf. Deadpool then goes and attacks a bunch of professors at a university before finically finding Humbug again, covering him in honey and throwing american fire ants on him. Then Frank appears and puts a leech in Deadpool's ear to help suck out the fluid that was blocking his eardrums.

In this issue, Deadpool is still in space fighting with Dirty Wolff to get back to Earth. On Earth, Skeeter and Frank are shipping stolen cars but run into Absorbing Man (Skeeter/Titania's husband), who thinks that his wife is home, sick in bed. When Frank asks Skeeter about it, she says not to worry about it. Finally, at the end of the issue, Deadpool makes it back to Earth.

Favorite line:
"If you're gonna grab my chest...at least buy me dinner and a movie..."-Deadpool to Dirty Wolff.

In this issue, we pick up with Deadpool finding out that Achebe wants him to find and return his "pet" leopard, which turned out to be a set up because it wasn't his pet at all...which lands Deadpool in a fight with a few of the Avengers.

In this issue, Skeeter and Frank are being held up in a lab. When "Skeeter" shape shifts into a guard, she gets out and escapes. But then she takes the form of their relator and Deadpool ends up kissing her, because he knows who "he" really is. This whole time it has been Mercedes that has been taking the form of Skeeter. They get into a fight which leads to the entire house blowing up. But because of Lokis curse, Deadpool wasn't even scratched. To cool down, he goes to a bar looking to pick a fight. But he ends up trying to pick a fight with an older man that isn't having it. Deadpool ends up coming to terms with the guy and then leaves. When he's outside he realizes that the Tom Cruiz look is gone and he's finally looking "normal." When he goes back to talk to the guy that must be his dad, the man is gone.

In this issue, Deadpool and Vanessa are hanging out like a "normal" couple. When they wake up together, Deadpool leaves for his mission and Vanessa hears a voicemail comes in from Theresa...and of course she gets jealous and disguises herself as Deadpool and beats her up. Meanwhile, Deadpool of trying to accomplish his mission from two old ladies (to shoot a super fast running guy). Later, Vanessa confronts Deadpool about Theresa. Then Theresa shows up and slaps Deadpool. At the very end, Deadpool shoots the runner.

Favorite lines:
"Geronimo-larry-and-curly!"-Deadpool

With this issue, we start the Deadpool: Agent of Weapon X series. In the beginning, we get a status report saying that their project with Wolverine is going well and that the phase one of the project overall has been a success. Then we get a quick look at the people that the project has worked with so far and the missions they carried out. However, they are concerned with one...Deadpool. Meanwhile, Deadpool is on a stakeout and Sabertooth shows up to talk. Sabertooth tells Deadpool that Project X is back in action and that Deadpool needs to return with him. When Deadpool says no, Sabertooth shows him the upgrades Project X has given him. Eventually, Sabertooth gets Deadpool to the lab where he's injected with a serum that the lab doctors say will boost his regen-powers. To demonstrate, they then use an axe to chop off Deadpool's arm. It immediately begins to grow back and the lab guy says that it grows back stronger than before. With the serum, Deadpool's skin has also been healed. The catch...these effects only last one hour. He will have to return for more treatments. After thinking it over for an hour, Deadpool returns for treatment.

Favorite line:
"Lady and Gentlemen-- I give you now, that man who needs no introduction, (but he's getting one anyway)-- DEADPOOL -- Please no applause necessary. Just throw me money."-Deadpool

In this issue, Deadpool and Kane head off with a troop of men to investigate a situation in Iowa. The men don't last long, but Deadpool and Kane head into the city to investigate. They soon find a person that is a large flame. While Kane tries to attack it, the flame keeps saying its not his fault and that he can't control it. Deadpool tries making "your mama" jokes to get the flame guy to calm down and it works! As it turns out, the flame guy is just a kid. Before Deadpool can get the kid's name, Kane shoots the kid. Deadpool does not approve, and he and Kane get into a short fight. When Deadpool gets back to the headquarters, he demands to see the director. However, the director tries to give him his next mission: to kill Vanessa.

Favorite lines:
"Maybe we should leave him behind. The dude's like "Scooby and Shaggy"-level scared!"-Deadpool

After Kane suggests splitting up, Deadpool: "Oh, no you don't! Ive seen this movie before-- the funny guy always gets it! Right after the crippled guy, the black guy, and the teenagers having sex."

In this issue, Deadpool tries to get Vanessa to safety but Kane is after them. When Deadpool and Vanessa try to leave the apartment, Kane tells them that this was a test and that Deadpool failed. They end up going to a zoo where Vanessa can transform herself into a gorilla while Deadpool goes to fight Kane. Even though Deadpool seems to have beaten Kane, Sabertooth got to Vanessa.

Meanwhile, one of the Project X leaders (Jackson) is checking on Creed (Sabertooth)...who has a house filled with dead bodies that he wants cleaned up as part of their "agreement." But Jackson says that the agreement was only for casualties in the line of duty, not on his free time. When Jackson checks out the closet, he finds a little girl that Creed was going to kill next and takes her out of the apartment. Jackson tries to call the head of Project X to tell them that something needs to be done about Creed, but he doesn't get anywhere and decides to deal with it on his own.

Favorite line:
When Deadpool is in the lions den at the zoo, "Um...you fellas wouldn't happen to be of the 'cowardly' variety now, would ya?"-Deadpool

"Now look what you made me of-- I killed Simbas father all over again!"-Deadpool

In this issue, we pick up with Deadpool taking his Project X chip out of his neck. Within a very short amount of time, the whole Project X army is after him. Deadpool leads them down an alley where he leave behind a bunch of explosives. When they go off, Deadpool escapes. However, one of the agents absorbed most of the blast, so the agents and mutants didn't all die. When Deadpool goes to the lab to take out as many agents as he can, he runs into Sabertooth. While they are fighting, Deadpool starts to turn back into mush. When the agents break Deadpool down until only his hand is left, they ship the hand to Wolverine (who also opposes Project X).

Favorite lines:
When Deadpool is cutting out the tech that the people of Project X put in him, he says goodbye to each thing. His final goodbye: "Goodbye Scarecrow... I think I'll miss you most of all."

"Nah-nah-na-nah-nah! Ya can't get me lucky charms Agent Jack-ass! See what I did there? I substituted 'ass' for 'son.' Tee hee..I made a funny."-Deadpool