The Unbeatable Squirrel Girl is the best comic thing I've read since the Bendis/Maleev run on Daredevil. And quite different, really.
Doreen is a very sympathetic and engaging character, and I love how she solves problems. The supporting cast is also great, and the books are so funny it's not to be believed.
Seriously, I won't shut up about this to the people I see in real life. Go out. Buy, borrow, or steal a copy of the first two volumes. You will thank me.