Reading this comic in the eighth grade was actually my first experience with Marvel media, so I'm probably bias in favor of it but in my opinion it's still one of the most inventive recent series I've ever read.

Each of the Runaways have distinct and differing personalities that are realistic as actual children and teenagers although it has now been over a decade since the first volume was originally written. 

As an adult I definitely see the characters as more childish than I did previously, but unless you typically dislike comics about teenagers I doubt their youth will bother or annoy you. 

While superheroes are still clearly shown to be a part of the world of the Runaways, they are distanced and isolated from them and have to fight overwhelming forces of evil on their bitter own which heightens the story to be suspenseful and exciting even though I've read it at least once already. 

If you're considering starting these comics because of the current Hulu show expect to see some clear differences, but I'm sure if you can put those aside you'll enjoy this series as much as I have for the last seven years.